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FMS Global News Korea, Characteristic electron microscopic findings in the skin of patients with

Kim SH, Kim DH, Oh DH, Clauw DJ.
Dongguk University College of Medicine, Gyeongju, South Korea, junjan@dongguk.ac.kr.

This blinded study was done to determine if there are any abnormal electron microscopic (EM) findings in the skin of fibromyalgia syndrome (FMS) patients, which might contribute to or be due to the increased pain sensitivity seen in this condition. Skin biopsy samples were obtained from 13 FMS patients and 5 control subjects. All tissues were prepared for EM examination by immediate prefixation in 2.5% glutaraldehyde for 2 h and postfixation in 1% osmium acid for 24 h. Ultrathin sections on grids were stained by uranyl acetate and lead citrate. Biopsies were read by an individual without knowledge of participant status. Five skin biopsies from healthy controls showed relatively even distribution of variegated sized unmyelinated axons sheathed well by complicatedly folded Schwann cell membranes. In tissues from 9/13 FMS patients, unmyelinated Schwann cells were noted to be ballooned, whereas this finding was not noted in any controls (p = 0.029). Axons in most patients trended towards being localized in the periphery of the unmyelinated Schwann cell sheaths (p = 0.002). Particularly, peripheral localization of axon in the unmyelinated Schwann cell sheath had a strong relationship with ballooning of Schwann cell (p = 0.042), simplified folding of Schwann cell sheath (p = 0.039) and smaller axon (p = 0.034). Myelinated nerve fibers were unremarkable. The EM findings seen in the skin of FMS patients show unusual patterns of unmyelinated nerve fibers as well as associated Schwann cells. If these findings are replicated in a larger study, these abnormalities may contribute to, or be due to, the lower pain threshold seen in FMS patients.

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October 12, 2007 Posted by | Uncategorized | , , , , | Leave a comment

FMS Global News October 12, 2007

Global Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome (CFS) News.

DID IT HAPPEN IN OUR LONDON?

by Jeanne Hambleton © 2007

This is reported to have happened in London – I don’t think so. Not our London, not the one in the UK with Westminster, Parliament and our new Prime Minister. Not our country where 2% of the population has fibromyalgia – they wouldn’t have the energy to do this. But who knows in these days of PC – politically correctness – anything goes.
This information was sent to me (as a journalist who might be interested) by email and looked like a newspaper cutting. It had no date and very little details about which newspaper this had been published in. It was however written by a reporter named Mike Foster (who I am sure is no relation to Dr Foster who went to Gloucester) who allegedly was writing for the Weekly World News.
The headline intrigued me. It read, “Nine oldsters booted out of nursing home – for trying to have an orgy!”
No it is not our London we don’t have “oldsters”, but I felt I had to read on wondering if it had anything to do with the News of he World, a renowned paper for a bit of juicy gossip. I worked with a former chief reporter of the NoW and he was capable of writing such a story.
The story reported nine “love-hungry” codgers were booted out of an old folks’ home after attempts to organise an orgy in the recreation room. Aged between 73 and 98 the ‘oldsters’ had been planning the late night event for weeks, said the “spokesperson from for the well respected nursing home”. The partygoers were celebrating one woman’s 90th birthday with a sex party.

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FMS Global News

Fibromyalgia Support

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October 12, 2007 Posted by | Uncategorized | , , , , , | 1 Comment

FMS Global News Report

Global Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome (CFS) News.

Fibromyalgia syndrome : New developments in pharmacotherapy.

Harten P.
Schwerpunkt Rheumatologie, Sophienblatt 1, 24103, Kiel, Deutschland, p.harten@web.de.

Fibromyalgia syndrome (FMS) affects 2-10% of the adult population in industrial countries and although it is associated with substantial morbidity and disability, treatment options are unsatisfactory. The rapid growth of trials for FMS in recent years has resulted in new, evidence-based approaches to medical treatment. This review focuses on the randomized, controlled studies of newer pharmacological options for FMS, such as selective serotonin/norepinephrine reuptake inhibitors (duloxetine, milnacipran), inhibitors of voltage-gated calcium channels (pregabalin, gabapentin), dopamine-2/3-receptor agonists (pramipexole, ropirinole), sedative-hypnotic agents (sodium oxybate, modafinil, dronabinol), 5-HT3 antagonists (tropisetron) and others (tramadol, dextromethorphan, olanzapine).

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October 10, 2007 Posted by | Fibromyalgia, Fibromyalgia News, FMS Global News, Global News | , , | 1 Comment